All SOLVAGREEN ® products as well as further information about the product can also be found in our current flyer Green Chemistry - Alternative Solvents and Products . ROTI ® Histofix ECO Plus SOLVAGREEN ® ready-to-use, formalin-free ROTI ® Histofix ECO Plus is a ready-to-use, aqueous solution on the basis of hexamethylene tetramine. The solution has similar good fixation properties like formaldehyde, but is, unlike formaldehyde, classified as non-toxic. Formaldehyde-free, non-toxic fixative Good fixation properties Optimal working range: pH 4,5-6,0 No denaturing effect, e.g. shrinkage or crosslinking Adequate substitute for formaldehyde The original morphology of the tissue is preserved during the fixation process. The protein molecules are cross-linked in a reversible way, their structures are preserved. That is especially important for antigen-antibody reactions. Samples are - in contrast to other fixative media - free of artefacts such as shrinkage of tissue or irreversible protein crosslinking. The solution is therefore ideal for immunohistochemistry. All conventional staining processes can be carried out following fixation. ROTI ® Histofix ECO Plus is provided with a fragrance for better identification (<1ppm). Not a medical device / Not an IVD product