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Anti-Fbx32 Antibody Rabbit polyclonal antibody to Fbx32. Not a medical device / Not an IVD product
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Anti-GSDMD (Full-length and C-terminal) Antibody Rabbit polyclonal antibody to GSDMD (Full-length and N-terminal). Not a medical device / Not an IVD product
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Anti-MMP14 Antibody Rabbit polyclonal antibody to MMP14. Not a medical device / Not an IVD product
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Anti-Connexin 43 / GJA1 Antibody Rabbit polyclonal antibody to Connexin 43 / GJA1. Not a medical device / Not an IVD product
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Anti-GAP43 Antibody Rabbit polyclonal antibody to GAP43. Not a medical device / Not an IVD product
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Anti-Cardiac Troponin T Antibody Rabbit polyclonal antibody to Cardiac Troponin T. Not a medical device / Not an IVD product
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Anti-Keap1 Antibody Rabbit polyclonal antibody to Keap1. Not a medical device / Not an IVD product
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Anti-ATPB Antibody Rabbit polyclonal antibody to ATPB. Not a medical device / Not an IVD product
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This antibody portfolio includes a wide range of tissue- & tumor-specific primary antibodies for basic research, product development and analysis of a variety of biological questions. The monoclonal antibodies are perfectly applicable for all cell or tissue biology studies and for the analysis of predictive markers in research. High epitope affinity Highly specific detection of the target protein Unconjugated Suitable for e.g. western blot, immunoprecipitation, ELISA & immunofluorescence anti-Uroplakin III mouse monoclonal, AU1 100 μg/ml, monoclonal, affinity purified Mab AU1 reacts specifically with uroplakin III present in the superficial cell layer of the urothelium. The binding region has been localized on the extracellular part of the antigen. Together with the uroplakins UP Ia, UP Ib and UP II, uroplakin III contributes in constituting the asymmetrical unit membrane of the plaques of urothelial superficial (umbrella) cells. Uroplakin is a membrane glycoprotein (47 kDa) and has been shown to be a specific marker of terminal urothelial differentia-tion (Wu et al. 1993 & 1194). Antibody AU1 strongly stains the urothelial surface membrane in paraffin sections of human renal pelvis, ureter, bladder, and urethra. About 60% of human transitional cell carcinomas (including metastases) maintain focal (sometimes very limited) expression of uroplakin III. Until now, no uroplakin staining was found in any non-urothelial carcinoma (Moll et al. 1995). Uroplakin III may thus serve as a specific urothelial differentiation marker in cases of metastatic carcinomas with unclear primary tumor. Moll, R., Wu, X.-R., Lin, J.-H. & Sunt, T.-T. Uroplakins, Specific Membrane Proteins of Urothelial Umbrella Cells, as Histological Markers of Metastatic Transitional Cell Carcinomas. Am. J. Pathol. 147, 1383-1397 (1995). Wu, X.-R. et al. Mammalian Uroplakins: A group of highly conserved urothelial differentiation-related membrane proteins. J. Biol. Chem. 269, 13716-13724 (1994). Wu, X. R. & Sun, T. T. Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell surface glycoprotein. J. Cell Sci. 106, 31-43 (1993). Application Immunohistochemistry (IHC) - paraffin: 1:20-1:60 (1.6-5 μg/ml; microwave treatment recommended) Western Blot (WB): 1:4,000-1:20,000 (0.005-0.025 μg/ml) IHC of rat bladder (courtesy of J.Heß, University Hospital Heidelberg) Western blot analysis of human bladder whole tissue lysate with anti-Uroplakin III antibody. Western blot analysis was performed on 3 μg and 2 μg bladder lysate. The PVDF membrane was blocked with 5% dry milk in PBST (PBS + 0.1% Tween 20) for 1 h at RT. The primary antibody anti-Uroplakin III mouse monoclonal, AU1 (Cat. No. 690108) was diluted in blocking buffer (antibody concentration 0.005 μg/ml) and incubated at RT for 1 h. The secondary antibody goat anti-mouse HRP was also diluted in blocking buffer (antibody concentration 0.2 μg/ml) and incubated for 1 h at RT. The bands were visualized by chemiluminescent detection using Pierce™ ECL Western Blotting Substrate. Not a medical device / Not an IVD product
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Anti-Mannose Receptor Antibody [15-2] Mouse monoclonal [15-2] antibody to Mannose Receptor. Not a medical device / Not an IVD product
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Anti-TIMP1 Antibody Rabbit polyclonal antibody to TIMP1. Not a medical device / Not an IVD product
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Anti-5-Methylcytosine / 5mC Antibody [ARC50801] Rabbit monoclonal [ARC50801] antibody to 5-Methylcytosine / 5mC. Not a medical device / Not an IVD product
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© 2023 Copyright. All Rights Reserved. Unit 19, Euroway House, Roydsdale Way, Bradford, BD4 6SE, UK
