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Penicillin G sodium salt CELLPURE ® ≥1550 I.U./mg Inhibits cell wall biosynthesis in gram-positive bacteria by irreversible interaction with transpeptidase. Application equivalent to Penicillin G potassium salt. Preferable when addition of potassium is to be avoided. Endotoxins: ≤0.25 E.U./mg
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Carbenicillin disodium salt ≥88 %, for biochemistry Carbenicillin inhibits cell wall biosynthesis in bacteria. Compared to ampicilline, carbenicillin is more resistant to hydrolysis by β-lactamase.
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Geneticin disulphate (G418 Sulphate) ≥650 U/mg, for biochemistry Inhibits protein biosynthesis by binding to ribosomes, particularly to eukaryotic 80S ribosomes. Through interference with the tRNA docking process, sequence errors appear and the elongating peptide chain is truncated. Geneticin disulphate unspecifically effects all cells, and is highly toxic for eukaryotic cells. Resistance is mediated by the bacterial enzyme aminoglycoside-3-phosphotransferase. Application: Selection of transfected eukaryotic cells. Resistance gene: Neomycin.
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Rifampicin ≥90 %, for biochemistry Rifampicin inhibits bacterial DNA-dependent RNA-polymerase and consequently prevents transcription. Its spectrum of activity is strictly bacterial (the eukaryotic DNA-dependent RNA-polymerase can only be inhibited at extremely high concentrations) and rifampicin is particularly very effective against mycobacteria. Enterbacteria, acinetobacteria and pseudomonades are resistant against rifampicin. The resistance-mediating genes can be applied as selection markers in molecular biology. Light-sensitive. Store in the dark!Stock solution: 100 mg/ml in chloroform or DMSO, 15 mg/ml in methanol, 1 mg/ml in water (pH 7,3)Store stock solution at -20 °C, is stable for approx. 2 weeks in DMSO when stored in the dark at 4 °CWorking concentration: 20-200 µg/ml
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Actinomycin D ≥950 μg/mg, for biochemistry Specific inhibitor of DNA-dependent RNA-synthesis. Inhibition is caused by intercalation in dsDNA and, therefore, is not specific for procaryotic cells. Standard application is the preparation of cDNA. Actinomycin D is cytostatic, toxic and sensitive to light. Stock solution should be kept in a bottle covered with foil.
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Cycloheximide ≥90 %, for biochemistry Antibiotic isolated from Streptomyces griseus . Its main biological activity is translation inhibition in eukaryotes by binding to the 60S subunit of the ribosomes. Cycloheximide inhibits binding of Aminoacyl-tRNA to the ribosomes, Peptidyltransferase, detachment of deacylated tRNA, and translocation of Aminoacyl-tRNA, resulting in cell growth arrest and apoptotic cell death. Not effective against bacteria. Cycloheximide is widely used for selection of cycloheximide-resistant strains of yeast and fungi, for inhibition of eukaryotic contaminants in bacterial microbiology, for controlled inhibition of protein synthesis in cell culture and for detection of short-lived proteins, and for apoptosis induction or facilitation of apoptosis induction by death receptors.
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Cefsulodin sodium salt ≥97 %, for biochemistry Semi-synthetic third generation cephalosporin derivate. Cefsulodin interferes with peptidoglycan layer composition during cell wall synthesis and is effective against a broad spectrum of gram-positive and gram-negative bacteria. Also active against anaerobes. Stable against cleavage by β-lactamase.
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Vancomycin hydrochloride CELLPURE ® ≥900 U/mg Inhibits bacterial cell cleavage through binding to cell membrane pre-stages. Endotoxins: ≤0.33 E.U./mg
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Cefotaxime sodium salt 916 - 964 μg/mg dried basis , USP Cefotaxime is a beta-lactamase-resistant antibiotic from the cephalosporin class. The antibiotic acts by binding to penicillin-binding proteins and thus inhibits bacterial cell wall synthesis. Not a medical device / Not an IVD product
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Penicillin G sodium salt CELLPURE ® ≥1550 I.U./mg Inhibits cell wall biosynthesis in gram-positive bacteria by irreversible interaction with transpeptidase. Application equivalent to Penicillin G potassium salt. Preferable when addition of potassium is to be avoided. Endotoxins: ≤0.25 E.U./mg
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Kanamycin ≥750 I.U./mg, for biochemistry Kanamycin inhibits protein biosynthesis and is effective against gram-negative and gram-positive bacteria. Easily water-soluble, stable powder.
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Nourseothricin ≥85 %, for biochemistry and microbiology Antibiotic of the streptothricine family, effective against a broad spectrum of viruses, bacteria and fungi. Used as selection antibiotic for genetically modified bacteria, yeasts, filamentous fungi, protozoa and plants. Nourseothricin inhibits biosynthesis and induces miscoding. Resistance is mediated by the sat1 encoded N-acetyltransferase, which inactivates nourseothricin by acetylation of the β-amino group of the β-lysin. Streptothricine F: n=1 (MW 599.59), Streptothricine D: n=3 (MW 857.95) Recommendation: One package Nourseothricin should be solubilized in whole and the stock solution should be frozen in aliquots. By removing the overlaying argon during weighing, the stability of the lyophilsate is reduced.
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