Tetrahydrofuran is a solvent for liquid chromatography-mass spectrometry (LC-MS), categorized under chemicals, solvents, solvents for chromatographic applications, and specifically solvents for LC-MS. It belongs to the oxygen heterocycles substance group with a Molecular Weight of 72.11 g/mol. In the workplace, it is labeled as a prohibited substance, requiring no open flames, fire, or smoking, and only authorized personnel are allowed access. The recommended indicative occupational exposure limit value for the European Union is an 8-hour limit value of 150 mg/m3 (50 ppm) and a short-term limit value of 300 mg/m3 (100 ppm). Tetrahydrofuran is highly flammable, causing skin irritation, and should be handled with caution due to its inflammable nature. Safety measures such as wearing safety goggles and gloves are advised.

• CAS Number: 109-99-9
• Molecular Formula: C4H8O
• Molecular Weight: 72.11
• Exact Mass: 72.057514874
• Boiling Point: 151 °F at 760 mmHg (NTP, 1992)
• Melting Point: -163.3 °F (NTP, 1992)
• Vapour Density: 2.5 (NTP, 1992) - Heavier than air; will sink (Relative to Air)
• GHS Signal Word: Danger
• Hazard Statements:
• H225: Highly Flammable liquid and vapor [Danger Flammable liquids]
• H315: Causes skin irritation [Warning Skin corrosion/irritation]